© Denise Leong

The 17th International p53 Workshop

   8-12 July 2017
   Biopolis, Singapore

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Program

Program of Events for the 17th International p53 Workshop

Breakthrough Theatrette, Matrix Level 4, Biopolis, Singapore


Saturday 8 July, 2017
1500 - 1700 Registration
1700 - 1840 Session 1: Welcome & Keynote
1700 - 1720
Welcome - Kanaga Sabapathy

Guest of Honour- Mr. Lim Chuan Poh, Chairman A*STAR

1720 - 1800 David Lane p53: Guardian of the genome ... but how?
1800 - 1840 Arnold Levine Possible Mechanisms for Some of the Mutant p53 Gain of Function Phenotypes
1840 - 2000 Reception

Sunday 9 July, 2017
0800 - 0900 Registration
0900 - 0950 Session 2: p53 and Li-Fraumeni syndrome
0900 - 0920 David Malkin Utilizing genomes and epigenomes to refine tumour surveillance in
Li-Fraumeni Syndrome
0920 - 0935 Yong Li TP53 noncoding germline mutation: beyond LFS
0935 - 0950 Gaelle Bougeard Genotoxic chemotherapies and X-rays are responsible for the development of multiple primary tumours in patients with Li- Fraumeni syndrome
0950 - 1020 Morning Tea
1020 - 1210 Session 3: p53, stem cells and epigenetic regulation
1020 - 1040 Koji Itahana Novel roles for p53 in maintaining embryonic stem cell homeostasis and quality
1040 - 1100 Galina Selivanova p53 controls a global epigenetic program to suppress tumour development
1100 - 1120 Andrei Gudkov p53 as a guardian of DNA "repeatome": cancer and aging implications
1120 - 1140 Yoshiaki Ito The inter-dependent roles of tumour suppressors RUNX and p53 in maintaining homeostasis and safeguarding the genome
1140 - 1155 Bae Suk-Chul Runx3 defends against endogenous oncogenic K-Ras-induced tumourigenesis
1155 - 1210 Frank McKeon p63+ stem cells in lung regeneration and COPD: Hope through heterogeneity?
1210 - 1330 Lunch
1330 - 1445 Session 4: p53, microbial interactions and metabolism
1330 - 1350 Michael Resnick The influence of p53 on innate immune responses and disease implications
1350 - 1410 Karen Vousden Metabolic functions of wild type and mutant p53
1410 - 1430 Gerard Evan Treating cancers by targeting oncogenic engines, not their drivers
1430 - 1445 Daniel Menendez p53 enhances innate immune responses via a TLR8 SNP
1445 - 1730 Afternoon Tea & Poster Session 1
1800 - 2200 Night Safari

Monday 10 July, 2017
0830 - 0900 Registration
0900 - 1045 Session 5: p53 Regulation and targets
0900 - 0920 Giovanni Blandino Aberrant crosstalk between the HIPPO and p53 tumor suppressor pathways elicits unrestrained cell proliferation
0920 - 0940 Robin Fahraeus The p53 mRNA and MDM2 guide ATM to the nascent p53 protein
0940 - 1000 Joaquin Espinosa Identification of a core p53 transcriptional program with highly distributed tumor suppressive activity
1000 - 1015 Reiko Ohki Identification of a novel p53 downstream pathway important in neuroendocrine tumor development
1015 - 1030 Ashish Lal Long non-coding RNA PINCR regulates a subset of p53 targets by binding to Matrin 3
1030 - 1045 Kurt Engeland BRCA1 and BRCA2 regulation by p53
1045 - 1110 Morning Tea
1110 - 1300 Session 6: p53 Targets and Functions
1110 - 1130 Wei Gu Ferroptosis: A missing puzzle piece in tumor suppression ?
1130 - 1150 Chen Xinbin Ninjurin 1 and Ferredoxin Reductase are regulated by p53 and in turn Regulate Wild-Type p53-Dependent Tumor Suppression and Mutant p53-Mediated Tumor Progression
1150 - 1210 Matthias Dobbelstein p53 activity results in DNA replication fork processivity
1210 - 1230 David Meek A novel protective role for p53 in maintaining centrosome separation
1230 - 1245 Cheng-Ming Chiang Phospho-BRD4-Targeting Compounds Effectively Block p53-Dependent Transcription and Gene Reprogramming
1245 - 1300 Jim Manley p53-dependent non-apoptotic methuosis-like cell death occurs in cells depleted of the ALS-related protein C9ORF72
1300 - 1400 Lunch
1400 - 1530 Session 7: Mutant p53 regulation
1400 - 1420 Carol Prives Regulation of cellular processes by wild-type and mutant forms of p53 and Mdm2.
1420 - 1440 Giannino Del Sal Mechanical cues control mutant p53 stability and function through a Mevalonate/RhoA axis
1440 - 1500 Andreas Strasser c-MYC and P19/ARF-driven stability of mutant TP53 is a targetable vulnerability in cancer
1500 - 1515 Tomoo Iwakuma Regulation of mutant p53 stability through the mevalonate pathway-DNAJA1 axis
1515 - 1530 Luis Martinez Mutant p53 stimulates NFkB by blocking a novel negative regulator, RasaL2
1530 - 1730 Afternoon Tea & Poster Session 2
1800 - 2100 Conference Dinner at Keppel Club

Tuesday 11 July, 2017
0830 - 0900 Registration
0900 - 1025 Session 8: p53, cancer and trials
0900 - 0920 Scott Lowe New insights into how p53 mutations drive tumorigenesis
0920 - 0935 Hugues de The Molecular insights of APL cure as P53-driven therapy-induced senescence
0935 - 0950 Min Lu Trials targeting p53 mutation in hematologic malignancies
0950 - 1010 Chit Fang Cheok Synthetic lethal drug repositioning presents new therapeutic opportunities in the p53 pathway
1010 - 1025 Susan Critchlow Exploiting cancer replication stress using pharmacology inhibitors of Wee1
1025 - 1100 Morning Tea
1100 - 1230 Session 9: p53 Structure
1100 - 1120 Alan Fersht How can aggregating p53 be rescued?
1120 - 1140 Chandra Verma The curious role of disorder in maintaining p53 stability
1140 - 1200 Varda Rotter Can mutant p53 be reeducated into a wild type p53, guardian of the genome?
1200 - 1215 Haim Rozenberg Multi-Way Restoration Of Oncogenic p53 Mutants By Second-Site Suppressor Mutations
1215 - 1230 Tali Haran The functional role of DNA spacers in p53 response elements
1230 - 1400 Lunch
1400 - 1535 Session 10: Therapeutic targeting of p53
1400 - 1420 Klas Wiman Targeting missense and nonsense mutant p53 for improved cancer therapy
1420 - 1440 Kanaga Sabapathy New toolkits for targeting p53
1440 - 1500 Sonia Lain A simple p53-based phenotypic screening strategy can be used to identify potent and cancer cell specific molecules
1500 - 1520 Ygal Haupt MDM4 as a therapeutic target for hormone-related cancers with wild type and mutant p53
1520 - 1535 Maria Ahn Development of a potent class of small molecule inhibitors of the MDM2-p53 protein-protein interaction
1535 - 1730 Afternoon Tea & Poster Session 3
1900 - 2100 Speakers dinner

Wednesday 12 July, 2017
0830 - 0845 Registration
8:45 - 1030 Session 11: p53 and mouse models
8:45 - 9:05 Guillermina Lozano Somatic p53 mutations drive development of triple negative breast cancer with evolutionary distinct metastases
9:05 - 0925 Laura Attardi Deconstructing p53 transcriptional networks in tumor suppression
0925 - 0945 James Manfredi Basal and induced gene expression by p53 are distinctly regulated in a tissue-specific manner and contribute to cell fate outcomes in vivo.
0945 - 1000 Franck Toledo The Guardian of the Genome revisited : p53 downregulates genes required for telomere maintenance, DNA repair, and centromere structure
1000 - 1015 Isabella Saggio Mice with reduced expression of the telomeric protein AKTIP/Ft1 display TP-53 sensitive progeroid properties
1015 - 1030 Yi Sun The Mdm2-MRN-ATM and Mdm2-p53 axes mediate radiosensitivity upon inactivation of ribosomal protein S27-like
1030 - 1100 Morning Tea
1100 - 1305 Session 12: p53 isoforms and family members
1100 - 1120 Curtis Harris p53 isoforms, Aging and Cancer
1120 - 1140 Jean-Christophe Bourdon p53: a system of p53 protein isoform orchestrating tissue regeneration?
1140 - 1155 Antony Braithwaite Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
1155 - 1210 Marco M Candeias Cancer-specific mutations induce IRES-dependent expression of short p53 isoforms leading to cancer cell survival, invasion and growth
1210 - 1230 Gerry Melino Mutp53 & TAp73 regulates tumour microenvironment via hypoxia-inducible factor-1α
1230 - 1250 Ute Moll TAp73 is a master transcriptional regulator of airway multiciliogenesis upstream of FoxJ1
1250 - 1305 Jo Huiqing Zhou EEC syndrome p63 mutations affect epidermal cell identity through rewiring the enhancer landscape
1305 - 1400 Lunch
1400 - 1730 Session 13: p53 family members
1400 - 1420 Moshe Oren p53 is essential for DNA methylation fidelity in naive embryonic stem cells and its loss promotes clonal heterogeneity
1420 - 1440 Volker Doetsch Mechanism of inhibition and activation of TAp63α in oocytes
1440 - 1500 Thorsten Stiewe Fanconi anemia DNA repair pathway: role for cellular response to small molecule RITA and regulation by p63
1500 - 1520 Caterina Missero Functional and mechanistic insights into the pathogenesis of p63-associated disorders
1520 - 1535 Jin Zhang The role of the p63-Rbm38 loop in Premature Aging and Tumor Suppression
1535 - 1550 Zhi-Xiong Jim Xiao Function and Regulation of p53 and p63 in Cancer Metastasi
1550 - 1605 Marco Napoli lncRNAs regulated by p63 in metastatic breast cancer
1605 - 1730 Concluding Remarks by David Lane and Arnold Levine followed by Networking
1730 Home, Home Sweet Home